Helmut Kettenmann教授，德国科学院院士、欧洲人文和自然科学院院士，德国洪堡大学终身教授，曾任德国神经学会主席，欧洲联合神经学会主席，Glia期刊创始人和主编，中国国家重大人才工程-“长江学者奖励计划”讲席学者，中国科学院“国际人才计划-特需外国人才”，深圳市高层次专业人才-杰出人才。Helmut Kettenmann教授在海德堡大学获得生物学硕士学位（与迈阿密大学联合培养，1980），生物学博士学位（1982年），并于1987年获特许任教资格。Helmut Kettenmann教授于2021年正式加入深圳理工大学，任神经生物学系系主任、讲席教授，同时兼任中国科学院深圳先进技术研究院脑认知与脑疾病研究所研究员。

胶质细胞的生理与病理功能

1.Kuhrt LD, Motta E, Elmadany N, Weidling H, Fritsche-Guenther R, Efe IE, Cobb O, Chatterjee J, Boggs LG, Schnauß M, Diecke S, Semtner M, Anastasaki C, Gutmann DH, Kettenmann H. (2023) Neurofibromin 1 mutations impair the function of human induced pluripotent stem cell-derived microglia. Dis Model Mech. 16:dmm049861.

2.Kompier N, Semtner M, Walter S, Kakabadze N, Steinhäuser C, Nolte C, Kettenmann H (2024) Membrane properties and coupling of macroglia in the optic nerve. Curr Res Neurobiol. 7:100137.

3.Kettenmann H (2024) A Novel Astrocyte-Neuron Interaction to Control Complex Animal Behavior. Neurosci Bull. doi: 10.1007/s12264-024-01328-6

4.Ugursu B, Sah A, Sartori S, Popp O, Mertins P, Dunay IR, Kettenmann H, Singewald N, Wolf SA. (2024) Microglial sex differences in innate high anxiety and modulatory effects of minocycline. Brain Behav Immun. 2024 Jul;119:465-481

5.Yalcin F, Haneke H, Efe IE, Kuhrt LD, Motta E, Nickl B, Flüh C, Synowitz M, Dzaye O, Bader M, Kettenmann H. (2024) Tumor associated microglia/macrophages utilize GPNMB to promote tumor growth and alter immune cell infiltration in glioma. Acta Neuropathol Commun.;12:50.

The Kettenmann lab has been studying the functions of all the three major types of glial cells in the brain, the astrocytes, oligodendrocytes and microglial cells. One goal is to analyze how astrocytes and oligodendrocytes are connected via gap junctions to form a panglial network and how this network influences neuronal function in the white and in the grey matter. A major focus of the lab is on the role of microglial cells in the normal and in the pathologic brain. The Kettenmann team found that microglial cells can express classical neurotransmitter receptors formerly considered to be a hallmark of neurons. Activation of these receptors influences microglial functions. Within the context of pathology they are currently studying the importance of microglial cells in stroke, Alzheimer’s disease and psychiatric diseases. Another line of research addresses the question how microglia interact with glioma cells. They aim to understand this interaction on a molecular level with the goal to identify therapeutic targets.