刘畅,研究员,博士生导师,中国科学院重点人才计划入选者,深圳市海外高层次人才。2003年本科毕业于河北师范大学,为中国科学院昆明动物研究所和德国马克斯-普朗克神经生物学研究所联合培养博士,2012年博士毕业后,在美国布兰迪斯大学开展博士后研究。研究方向聚焦于睡眠和学习记忆的神经环路以及分子机制的研究,以及睡眠障碍和认知衰退诊疗干预的新靶点和策略的研究。
睡眠和记忆
1. Wei Yan#, Zijie Li#, Ziyi Lin, Shuqin Ji, William Ka Fai Tse, Zhiqiang Meng, Chang Liu*, Lei Li*. Microplastics exposure disturbed sleep structure, reduces the lifespan and ovary size of Drosophila melanogaster. Zoological Research, 2024, 45(4):805-820 (cover paper) 2. Litao Wu, Chang Liu*. Integrated neural circuits of sleep and memory regulation in Drosophila. Current Opinion in Insect Science, 2023, 59:101105. 3. Wei Yan, Hai Lin, Junwei Yu, Timothy D. Wiggin, Litao Wu, Zhiqiang Meng, Chang Liu*, Leslie C. Griffith*. Subtype-specific roles of ellipsoid body ring neurons in sleep regulation in Drosophila. Journal of Neuroscience, 2023, 43(5):764–786 (cover paper) 4. Chang Liu*, Zhiqiang Meng#, Timothy D. Wiggin#, Junwei Yu, Fang Guo, Martha Reed, Yunpeng Zhang, Michael Rosbash, Leslie C. Griffith*. A serotonin-modulated circuit controls sleep architecture to regulate cognitive function independent of total sleep in Drosophila. Current Biology, 2019, 29(21):3635-3646. 5. Chang Liu, Pierre-Yves Plaçais, Nobuhiro Yamagata, Barret D. Pfeiffer, Yoshinori Aso,Anja B. Friedrich, Igor Siwanowicz, Gerald M. Rubin, Thomas Préat, Hiromu Tanimoto*. A subset of dopamine neurons signals reward for odour memory in Drosophila. Nature, 2012, 488(7412):512-6
代表性成果累计发表包含Nature、PNAS、Current Biology、Journal of Neuroscience等SCI论文20余篇,授权专利10项(含转出1项)。主持国家自然科学基金专项项目、面上项目、中国科学院率先行动引才计划项目、广东省基础与应用基础面上项目等10余项。联合培养博士毕业生1名。