王华东，副研究员，深圳市高层次人才。2012年获得中国科学院大学生物化学与分子生物学博士学位。研究方向为脑图谱神经环路示踪新技术新工具开发，肿瘤-神经互作网络研究，溶瘤病毒药物研制及质量评价研究等。为国家药品监督管理局细胞和基因治疗药物技术研究与评价重点实验室、广东省药监局病毒制剂质控技术重点实验室、深圳市生物医药病毒载体重点实验室核心骨干。深圳市细胞和基因产品检测评价专委会常务委员。

神经环路示踪技术、溶瘤病毒药物研制及质量评价

1.Yusha Sun#, Xin Wang#, Daniel Zhang, Zhijian Zhang, Janardhan Bhattarai, Yingqi Wang, Kristen Park, Weifan Dong, Yun-Fen Hung, Qian Yang, Feng Zhang, Keerthi Rajamani, Shang Mu, Benjamin Kennedy, Yan Hong, Jamie Galanaugh, Abhijeet Sambangi, Sang Hoon Kim, Garrett Wheeler, Tiago Gonçalves, Qing Wang, Daniel Geschwind, Riki Kawaguchi, Angela Viaene, Ingo Helbig, Sudha Kessler, Ahmet Hoke, Huadong Wang, Fuqiang Xu, Zev Binder, H Isaac Chen, Emily Ling-Lin Pai, Sara Stone, MacLean Nasrallah, Kimberly Christian, Marc Fuccillo, Nicolas Toni, Zhuhao Wu, Hwai-Jong Cheng, Donald O'Rourke, Minghong Ma, Guo-Li Ming*, Hongjun Song*. Brain-wide neuronal circuit connectome of human glioblastoma. Nature. 2025 Jan 16. doi: 10.1038/s41586-025-08634-7.

2.Yan Chen#, Yuran Song#, Huadong Wang#, Yiyun Zhang, Xinyu Hu, Kaikai Wang, Yingjin Lu, Zoutao Zhang, Shuai Li, Anan Li, Lan Bao, Fuqiang Xu, Changlin Li*, Xu Zhang*. Distinct neural networks derived from galanin-containing nociceptors and neurotensin-expressing pruriceptors. Proc Natl Acad Sci U S A. 2022 Aug 16;119(33):e2118501119.

3.Min Ying#, Huadong Wang#,*, Tongtan Liu, Zengpeng Han, Kunzhang Lin, Qing Shi, Ning Zheng, Tao Ye, Huinan Gong, Fuqiang Xu*. CLEAR Strategy Inhibited HSV Proliferation Using Viral Vectors Delivered CRISPR-Cas9. Pathogens. 2023 Jun 7;12(6):814.

4.Bing Cai#, Dan Wu#, Hong Xie#, Yan Chen, Huadong Wang, Sen Jin, Yuran Song, Anan Li, Shiqi Huang, Sashuang Wang, Yingjin Lu, Lan Bao, Fuqiang Xu, Hui Gong, Changlin Li*, Xu Zhang*. A direct spino-cortical circuit bypassing the thalamus modulates nociception. Cell Research. 2023 Oct;33(10):775-789.

5.Peng Su#, Min Ying#, Zengpeng Han, Jinjin Xia, Sen Jin, Yingli Li, Huadong Wang*, Fuqiang Xu*. High-brightness anterograde transneuronal HSV1 H129 tracer modified using a Trojan horse-like strategy. Molecular brain. 2020; 13(1): 5.

代表性成果累计发表SCI论文30余篇，申请国家和国际发明专利24项，已获授权专利5项。主持国家自然科学基金青年基金、面上项目，广东省/深圳市面上项目等，作为核心骨干参与科技创新2030“脑科学与类脑研究”重大项目、国家重点研发计划、中科院战略先导专项、973项目等。在Nature, PNAS, Cell research, Cell Stem Cell, Emerging microbes & infections等杂志发表SCI论文30余篇。任Nature出版集团旗下期刊《Scientific Reports》编委，Frontiers in Pharmacology客座编委。培养/联合培养博士毕业生2名，硕士毕业生5名。