冯博，副研究员，博士生导师，中国科学院百人计划入选者，广东省珠江青年拔尖人才。上海交通大学学士，浙江大学博士，加州大学圣地亚哥分校博士后。研究方向为神经突触丢失的分子机制及相关疾病的药物靶点研究。1）关注胶质细胞与神经突触的相互作用及其在神经退行性疾病中的作用, 并发现相关的先导化合物；2）聚焦神经突触丢失的分子机制及其参与神经退行性疾病的作用，筛选潜在的治疗神经退行性疾病的单克隆抗体药物。

神经生物学

1. A Freitas, B Feng, T Woo, S Galli, C Baker, Y Ban, J Truong, A Beyeler, and Y Zou*. Planar cell polarity proteins mediate ketamine-induced restoration of glutamatergic synapses in prefrontal cortical neurons in a mouse model for chronic stress. Nature Communications, 2024

2. B Feng, A Freitas, L Gorodetski, R Tian, YR Lee, J Wang, A Grewal, and Y Zou*. Planar cell polarity signaling regulates adult synapse maintenance and is a direct target of amyloid-βassociated synapse degeneration. Science Advances 2021; 7 : eabh2307

3. Y Ban, T Yu, B Feng, C Lorenz, X Wang, C Baker, and Y Zou*. Prickle promotes the formation and maintenance of glutamatergic synapses by stabilizing the intercellular planar cell polarity complex. Science Advances

4. Y Wan#, B Feng#, Y You#, J Yu, C Xu, H Dai, B Trapp, P Shi, Z Chen*, W Hu*. Microglial Displacement of GABAergic Synapses Is a Protective Event during Complex Febrile Seizures. Cell Reports 2020 33 (5), 108346 (#Equal Contribution)

5. Y Tang#, B Feng#, Y Wang, H Sun, Y You, J Yu, B Chen, C Xu, Y Ruan, S Cui, G Hu, T Hou, and Z Chen* Structure‐based discovery of caspase‐1 inhibitor with therapeutic potential for febrile seizures and later enhanced epileptogenic susceptibility. British Journal of Pharmacology 177:3519–3534 (#Equal Contribution)

相关研究成果发表在Science Advances，Nature Communications, Cell Reports, PNAS, British J Pharmacology等国际知名期刊。主持国家自然科学基金，中国科学院率先行动引才计划，广东省自然科学基金及深圳市基础研究等项目。