高亮
高亮
个人简介

高亮,副研究员,硕士生导师,深圳市级人才。2014年获德国海德堡大学博士学位。2015年至2017年在德国癌症研究中心从事博士后研究。现从事免疫稳态的神经调控机制研究,以中枢神经系统免疫相关疾病为切入点,解析疾病进展中免疫稳态失衡的神经调控作用机理。

研究领域

神经免疫

代表论著

1. Kuo Lu, Keng Po Lai, Tobias Stoeger, Shuqin Ji, Ziyi Lin, Xiao Lin, Ting Fung Chan, James Kar-Hei Fang, Michael Lo, Liang Gao, Chen Qiu, Shanze Chen, Guobing Chen , Lei Li, Lingwei Wang. Detrimental effects of microplastic exposure on normal and asthmatic pulmonary physiology. J. Hazard. Mater. 2021;416:126069.

2. Gülcüler Balta, Gülce S., Cornelia Monzel, Susanne Kleber, Joel Beaudouin, Emre Balta, Thomas Kaindl, Si Chen, Liang Gao, Meinolf Thiemann, Christian R. Wirtz, Yvonne Samstag, Motomu Tanaka and Ana Martin-Villalba. 3D Cellular Architecture Modulates Tyrosine Kinase Activity, Thereby Switching CD95-Mediated Apoptosis to Survival. Cell Reports 29 (8): 2295-2306.e6. doi:10.1016/j.celrep.2019.10.054.

3. Dehler, Sascha, Wilson Pak-Kin Lou, Liang Gao, Maxim Skabkin, Sabrina Dällenbach, Andreas Neumann, and Ana Martin-Villalba. 2018. “An Immune-CNS Axis Activates Remote Hippocampal Stem Cells Following Spinal Transection Injury.” Frontiers in Molecular Neuroscience 11 (December): 1–12. doi:10.3389/fnmol.2018.00443.

4. Liang Gao, Gülce Sila Gülcüler, Lieke Golbach, Helena Block, Alexander Zarbock, and Ana Martin-Villalba*. 2016. “Endothelial Cell-Derived CD95 Ligand Serves as a Chemokine in Induction of Neutrophil Slow Rolling and Adhesion.” eLife 5 (OCTOBER2016): 1–20. doi:10.7554/eLife.18542.

5. Liang Gao#, David Brenner#, Enric Llorens-Bobadilla, Gonzalo Saiz-Castro, Tobias Frank, Peter Wieghofer, Oliver Hill, Meinolf Thiemann, Saoussen Karray, Marco Prinz, Jochen H. Weishaupt, and Ana Martin-Villalba*. 2015. “Infiltration of Circulating Myeloid Cells through CD95L Contributes to Neurodegeneration in Mice.” The Journal of Experimental Medicine 212 (4): 469–80. doi:10.1084/jem.20132423.

科研\学术成果

代表性成果累计发表SCI论文10余篇,授权专利2项。在国际上第一次报道了小鼠模型中髓系细胞的脑侵润能加剧神经退行性病变;同时也发现了一种新的诱导髓系细胞趋化的分子细胞机制,为从免疫调节角度治疗脑疾病提供了崭新思路。